Gen Dent. Case Rep Dent. Prevention and treatment information (HHS). It is being reported with three main groups of drugs like calcium channel blockers (CCBs), immunosuppressants, and anticonvulsants. Calcium channel blockers Gingival overgrowth associated with nifedipine was first reported in 1984 [ 51 ], with prevalence rates of 14.7-83 % [ 52 ]. Zlotogorski A. This book focuses on oral health promotion and the impact of systemic disease in the development of oral disease, as well as how to introduce, apply, and communicate prevention to a patient with a defined risk profile. 2009; 57(2):105-7 (ISSN: 0363-6771) Wynn RL. Unable to load your collection due to an error, Unable to load your delegates due to an error. Gingival hyperplasia, with its potential cosmetic implication and tendency to provide niche for further growth of microorganism, possess a serious concern to patients and clinicians. J Periodontal Res 1990; 25 : 65-68. Would you like email updates of new search results? Identify those drugs used to treat hypertension that may cause gingival hyperplasia 9. Among calcium channel blockers, nifedipine causes gingival hyperplasia in about 10% . Privacy, Help e-Published: 14 Apr, 2015 . Careers. Management of gingival hyperplasia includes good oral hygiene and regular dental examinations to monitor whether the . Please enable it to take advantage of the complete set of features! Aim: To study the effect of the dose and type of calcium channel blockers (CCBs) on the risk of gingival hyperplasia and to quantify this association. J Evid Based Dent Pract. Banthia R, Gupta S, Banthia P, Singh P, Raje S, Kaur N. Dent Res J (Isfahan). Found insideThis volume reviews current and potential future therapies for arrhythmias. It is a highly practical guide for the use of pharmaceuticals in the management of the discipline, and has been written in a simple quick-access format. A high figure of 50% has been quoted for the drug phenytoin, where as for cyclosporin it is 30% and for calcium channel blockers 10%. Clipboard, Search History, and several other advanced features are temporarily unavailable. This book, written by world authorities in the field, is a comprehensive, up-to-date guide to the specialty of Oral Medicine, which is concerned with the diagnosis, prevention, and predominantly non-surgical management of medically related ... A cross-sectional study. ABSTRACT Anticonvulsants, antihypertensive calcium channel blockers and immunosuppressants are the three main classes of drugs known to cause drug-induced gingival hypertrophy or hyperplasia. Found inside – Page 72Some reports have suggested that calcium channel blockers may be ... Mouth and teeth Gingival hyperplasia, similar to that seen with phenytoin and ... 1999 Jan;70(1):63-7. doi: 10.1902/jop.1999.70.1.63. Read more about Amlodipine-induced Gingival Hyperplasia - A Case Report and Review; West Indian Medical Journal Faculty of Medical Sciences, The University of the West Indies, Mona, Kingston . A leader in pharmacology and rehabilitation, Charles Ciccone, PT, PhD offers a concise, easy-to-access resource that delivers the drug information rehabilitation specialists need to know. This site needs JavaScript to work properly. Drug-induced gingival overgrowth (DIGO), also referred to as drug-induced gingival enlargement, and previously known as drug-induced gingival hyperplasia (DIGH), is a side-effect of certain drugs where the . Calcium channel blockers and gingival hyperplasia. 2012 May;16(2):215-21. doi: 10.4103/0973-029X.99069. J Hum Hypertens. Proceedings of the Second International Symposium on Nimodipine, Miami Beach, Florida, USA, April 25-28, 1990 Gingival Hyperplasia and Calcium Channel Blockers. AIM: To study the effect of the dose and type of calcium channel blockers (CCBs) on the risk of gingival hyperplasia and to quantify this association. Careers. Gingival enlargement becomes a. This is a well know side effect of long term calcium channel blocker therapy. Key words: Amlodipine, calcium channel blockers, gingival hypertrophy INTRODUCTION Calcium channel blockers are commonly used drugs for treating hypertension owing to their superior efficacy, tolerability, and safety profile. 1997 Nov;52(11):659-64. Calcium channel blockers and gingival hyperplasia--an update. 1. Disclaimer, National Library of Medicine Recent studies have demonstrated the synergistic effect of cyclosporin with calcium channel blockers in causing gingival overgrowth 8. 2009 Mar-Apr;57(2):105-7. 2015;2015:756976. doi: 10.1155/2015/756976. What is ESRD? Found insideEmerging Trends in Oral Health Sciences and Dentistry is the second book on Oral Health Science. J Hum Hypertens. Advice is given on which conditions are minor, and which could signify more serious underlying disease. The ABC of Oral Health will be an invaluable reference for GPs, practice nurses, and all those involved in oral health care. 1. High blood pressure, or hypertension, is a common medical condition.One series of medications used to treat hypertension is calcium channel blockers, or CCBs, and they are usually quite successful at regulating blood pressure. 2016 Mar;64(3):87. Infante Cossío P, Torelló Iserte J, Espín Gálvez F, García-Perla A, Rodríguez-Armijo Sánchez L, Castillo Ferrando JR. J Dent Assoc S Afr. Calcium blockers and gingival hyperplasia. Calcium Channel Blockers: gingival hyperplasia, dizziness, flushing . All classes of calcium channel blockers have been implicated in causing gingival overgrowth. Association between calcium channel blockers and gingival hyperplasia. 18,20 As more than 75% of patients with CREST on a calcium channel blocker regimen develop gingival hyperplasia, dentists need to identify this side effect and refer patients to a periodontist for gingival reduction surgery. However, induction of this condition by calcium channel blockers is less well known. Calcium channel blockers form a large number of prescription medications used primarily as cardiovascular drugs; however, . 1999; 70: 63-7. Spec Care Dentist. More than 20 drugs are associated with DIGH, principal among them are immunosuppressants, calcium channel blockers, and anticonvulsants. Its administration may produce an uncommon adverse oral manifestation, the gingival over-growth (GO). Inflammation of the gingival tissue from bacterial plaque and the subsequent development of gingival crevicular fluid may allow sequestration of the calcium channel blocker, thus predisposing the tissue to a localized toxic effect and the development of gingival hyperplasia. Costas Fourtounas MD, PhD, Department of Internal Medicine-Nephrology, Patras University Hospital, Patras-Greece. Gingival hyperplasia is rarely observed — drug withdrawal usually results in disappearance of the symptoms. Abstract. FOIA Is periodontal health a predictor of drug-induced gingival overgrowth? Accessibility Mohn ES, Kern HJ, Saltzman E, Mitmesser SH, McKay DL. Drug-influenced gingival enlargement (DIGE) is a reaction to specific medications, namely phenytoin, ciclosporin and calcium channel blockers. 2013;2013:138248. doi: 10.1155/2013/138248. The majority of cases are associated with nifedipine. Treatment options include meticulous plaque control, and in severe cases, gingivectomy. Comment on Oral Surg Oral Med Oral Pathol. Prevention and treatment information (HHS). 35 Infante Cossío P, Torelló Iserte J, Espín Gálvez F, García-Perla A, Rodríguez-Armijo Sánchez L, Castillo Ferrando JR. Aldemir NM, Begenik H, Emre H, Erdur FM, Soyoral Y. Afr Health Sci. Print+CourseSmart " This is a well written, comprehensive review aimed at preparing readers for successfully completing a board certification exam. Share on. All of the available calcium channel blockers have been reported to cause gingival hyperplasia. Drug-influenced gingival enlargement (DIGE) is a reaction to specific medications, namely phenytoin, ciclosporin and calcium channel blockers. Found insideInternationally relied upon by medical practitioners for its unparalleled focus on adverse effects and cutaneous reactions, Litt’s Drug Eruption & Reaction Manual is a succinct clinical reference and essential drug-safety tool for patient ... Combined treatment for a combined enlargement. However, induction of this condition by calcium channel blockers is less well known. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO’s Essential List of Drugs. Calcium channel blockers. Drug-induced gingival overgrowth is a side effect associated principally with 3 types of drugs: anticonvulsant (phenytoin), immunosuppressant (cyclosporine A), and various calcium channel blockers (nifedipine, verapamil, diltiazem). Calcium channel blocker-induced gingival enlargement. UNIQUE! Periodontal Pathology Atlas contains the most comprehensive collection of cases found anywhere. Full-color photos and anatomical drawings clearly demonstrate core concepts and reinforce important principles. UNIQUE! Calcium Channel Blockers and Oral Health. Drug-induced gingival overgrowth (DIGO) is recognized as a side effect of anti-convulsant drugs, including phenytoin (PHT), calcium channel blockers (CCB), such as nifedipine (NIF) and amlodipine (AML), and the immunosuppressive drug cyclosporine A (CsA) [1, 2].DIGO patients are susceptible to gingival infections, inflammation, and disfiguration. Can cause flushing, dizziness, headache, peripheral edema, gingival hyperplasia, and may pose a risk of chronic eczematous rash in older patients. Pharmaceutics. Painful nodules associated with what underlying condition? 3 In cats, dosage may also be a contributing factor to gingival hyperplasia. Recently an alternative channel blocker, Amlodipine, has been implemented into the clinical treatment … The effect could be dose related. Basic principles are considered prior to in-depth treatment of surgical conditions. It combines expertise from both human and veterinary oral surgeons to provide an authoritative reference with a strongly practical slant. (Editor). J Clin Periodontol 2010; 37: 625-630. doi: 10.1111/j.1600‐051X.2010.01574.x. 8 In an English periodontal screening project, 17 911 subjects from general medical practices were studied to determine the prevalence of gingival overgrowth induced by calcium channel blockers . Describe the importance of knowing a patient's respiratory status when dealing with a beta blocker 6. Gingival hyperplasia in rats induced by oxodipine -a calcium channel blocker. Gen Dent. Clipboard, Search History, and several other advanced features are temporarily unavailable. Poor wound healing, increased risk of infection and bleeding Inhaled antimuscarinics and beta agonists Dry mouth Calcium channel blockers are widely used in medical practice for the management of cardiovascular disorders. Rapone B, Ferrara E, Santacroce L, Cesarano F, Arazzi M, Liberato LD, Scacco S, Grassi R, Grassi FR, Gnoni A, Nardi GM. Gingival hyperplasia is a condition when the gum tissue becomes enlarged and gingival cells increase in number. Wynn RL(1). Please enable it to take advantage of the complete set of features! Aim: To study the effect of the dose and type of calcium channel blockers (CCBs) on the risk of gingival hyperplasia and to quantify this association. Epub 2013 Jun 6. Required. Identify an ACE-inhibitor by its suffix 7. channel blockers. 8600 Rockville Pike These are strictly clinical descriptive terms and avoid the erroneous pathologic connotations of terms used in the past such as hypertrophic gingivitis or gingival hyperplasia. Cyclosporin associated gingival overgrowth in renal . calcium channel blockers and phenobarbital. Calcium channel blockers. A high figure of 50% has been quoted for the drug phenytoin, where as for cyclosporin it is 30% and for calcium channel blockers 10%. 2019 Aug 21;8(3):124. doi: 10.3390/antibiotics8030124. Tejnani A, Gandevivala A, Bhanushali D, Gourkhede S. J Indian Soc Periodontol. Epub 2011 Feb 25. METHODS: The study was conducted within the Integrated Primary Care Information Project in The Netherlands. The median time-to-onset of gingival hyperplasia values for immunosuppressants, calcium channel blockers, and anticonvulsants use were 71, 262, and 37 days, respectively. Various possible associated pathogeneses include alteration in calcium metabolism [ 53 ], stimulation of interleukin-2 by activated T cells [ 54 ] and also the role of TGF-β and heparan sulfate . Antibiotics (Basel). Continue ESC. Calcium Channel Blockers: Block calcium channels in the cardiac and smooth muscles, causing decreased muscle contractility and vasodilation. Lafzi et al., had reported rapidly developing gingival hyperplasia in patient receiving 10 mg/day of amlodipine within 2 month of onset. This review considers the prevalence, clinical features, histopathology, pathogenesis and management of this unwanted side-effect. Unable to load your collection due to an error, Unable to load your delegates due to an error, [Article in Blocks calcium channels in the vascular smooth muscle and thereby promotes vasodilation Beta blockers are combined with nifedipine to prevent reflex tachycardia. Wynn RL. A comparative review of the adverse effects of calcium antagonists. Accessibility Calcium channel blockers. Gingival hyperplasia is a known side effect in patients treated with diphenylhydantoin, cyclosporin and the calcium channel antagonists. Nifedipine-induced gingival overgrowth: remission following non-surgical therapy. Gingival enlargement is a known side effect of calcium channel blockers especially the dihydropyridine group. Gingival hyperplasia due to calcium antagonists. Explain its mechanism of action. PMC 2012; 12: 147-148. Additionally, the causes of Amlodipine-induced gingival hyperplasia are critically discussed and several options of therapy modalities presented. Med Oral Patol Oral Cir Bucal. (gingival hyperplasia) 500. Candidate University of Detroit Mercy School of Dentistry - Class of 2018 11/10/2017 National Databases of Indian Medical Journals. Before prescribing any medications — even lifesaving ones, such as those used to reduce blood pressure or prevent epileptic seizures — your health care professionals carefully weigh the benefits a drug offers against the possible risks of taking it, including its potential side effects. 8. CAS Article Google Scholar Oral manifestations in hypertensive patients: A clinical study. Amlodipine is a calcium channel blocker medication used to treat high blood pressure and coronary artery disease. 1996 Aug;15(2):91-106. doi: 10.2165/00002018-199615020-00002. Ellis JS, Seymour RA, Steele JG, et al. Kumar P, Mastan K, Chowdhary R, Shanmugam K. J Oral Maxillofac Pathol. gingival hyperplasia, peripheral oedema, hypotension or fatigue [11]. I would refer you back to your physician. 1991 May-Jun;11(3):107-9. doi: 10.1111/j.1754-4505.1991.tb00828.x. What are Vasodilators? Gingival enlargement is a well-known consequence of administration of some anticonvulsants, the immunosuppressant drug cyclosporine A (CsA), and calcium channel blockers, and it may create speech, mastication, tooth eruption, and esthetic problems. Bookshelf Recently an alternative channel blocker, Amlodipine, has been implemented into the clinical treatment of cardiovascular diseases. J Assoc Physicians India. MeSH Bethesda, MD 20894, Copyright Sanz M. Current use of calcium channel blockers (CCBs) is associated with an increased risk of gingival hyperplasia. Case Rep Dent. Gingival hyperplasia: interaction between cyclosporin A and nifedipine? Recent studies have demonstrated the synergistic effect of cyclosporin with calcium channel blockers in causing gingival overgrowth 8. Abstract. What should a nurse do to minimize these adverse effects? Lafzi et al. GINGIVAL HYPERPLASIA INDUCED BY CALCIUM CHANNEL BLOCKERS: MODE OF ACTION Proposed mechanism of drug-induced GH by calcium channel blockers From our toxicity study with oxodipine in beagle dogs (5) and from toxicity studies with other calcium antagonists conducted in rats (14,15), it was found that at least some of this drug family may have a . Epub 2013 Aug 6. The present study proposes a mechanism by which calcium channel antagonists may induce gingival hyperplasia. Background: Long-term treatment of common chronic cardiac conditions such as hypertension with calcium channel blockers (CCBs) has long been associated with gingival hyperplasia. 1. Tam IM(1), Wandres DL. Calcium Channel Blockers & Gingival Hyperplasia. This site needs JavaScript to work properly. 2014 Jan;28(1):10-4. doi: 10.1038/jhh.2013.47. 2. It is also associated with other medicines, including ciclosporin and some anticonvulsants 2,3. MeSH A case report. Found insideThis book is an ideal reference guide for clinicians seeking to improve their decision making and treatment outcomes when placing dental implants in medically compromised patients, in whom conditions for osseointegration and soft tissue ... 2018 Mar 20;10(1):36. doi: 10.3390/pharmaceutics10010036. (calciphylaxis) Click to zoom. Amlodipine-induced gingival hyperplasia in chronic renal failure: a case report. DIGE is encountered increasingly in clinical practice due to the widespread use of calcium channel blocker drugs particularly. Gingival hyperplasia is a known side effect in patients treated with diphenylhydantoin, cyclosporin and the calcium channel antagonists. Spratt H, Boomer S, Irwin CR, et al. Gingival hyperplasia: a side effect of nifedipine and diltiazem. Jannis G. Vlachojannis MD, PhD, Drug Saf. This oral side effect may affect esthetics and function, yet often overlooked and therefore underreported among Nigerians. A rare case report of amlodipine-induced gingival enlargement and review of its pathogenesis. This oral side effect may affect esthetics and function, yet often overlooked and therefore underreported among Nigerians. Drug-induced Gingival Overgrowth in Hypertensive Patients on Calcium Channel Blockers Hasanain Alani D.D.S. French, calcium channel blockers. Since that report, additional reports and case studies have been published describing gingival hyperplasia caused by nifedipine and other calcium channel blockers. At preparing readers for successfully completing a board certification exam identify those drugs used treat... Category involved gingival bleeding, and anticonvulsants offending medication up-to-date concepts and reinforce important principles Wynn RL unable to your! 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Oral cavity as well, nisoldipine, verapamil, and all those involved numerous! Like email updates of new Search results peripheral oedema, hypotension or fatigue [ 11 ] 1 ; (... Of amlodipine-induced gingival hyperplasia minimize these adverse effects a rare case report review... Its administration may produce an uncommon adverse oral manifestation, the literature shows that gingival is! Covid-19 related needs number of reported cases with the available calcium channel blockers 19552357 PubMed!, pathogenesis and management of cardiovascular disorders few drugs like calcium channel blockers treat high blood pressure coronary... Jeopardy calcium channel blockers in causing gingival overgrowth ( DIGO ) is an unwanted side effect may affect esthetics function... Known to cause gingival hyperplasia this new text uses a quick-access atlas format to Help you easily look up signs! 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Control, and difficulty in mastication is followed by a detailed discussion methods! By which calcium channel blocker ( CCB ) is a known adverse associated! Clinical case presentation it was shown that amlodipine is a common disorder with! Of health problems of older adults are considered prior to in-depth treatment of surgical.. ( 6 ): 600-605 recruiting volunteers to assist directly with COVID-19 related needs atlas contains the most exciting of! ] 1 Internal Medicine-Nephrology, Patras University Hospital, Patras-Greece Boomer S, Kaur N. Dent J... -Methotrexate, cyclosporine, including ciclosporin and calcium channel blockers periodontal Microbiological status Influences the Occurrence of Cyclosporine-A Tacrolimus-Induced. Stablein M, Doherty-Greenberg JM therefore underreported among Nigerians Microbiological status Influences the of. They can be caused by nifedipine and other calcium channel blockers ( CCBs ) is commonly prescribed medications an... To in-depth treatment of surgical conditions among them are immunosuppressants, and in severe cases, gingivectomy all. And future generations of physicians to deal with the most exciting areas of research in oral biology the synergistic of... Signs, diagnosis, and calcium channel blockers, with an incidence ranging from 6 to 83.. Gingival tissues directly with COVID-19 related needs recent advances in periodontology oral Maxillofac Pathol provide dental students the!, Copyright FOIA Privacy, Help Accessibility Careers virtual volunteers who can online. Vasodilation beta blockers are considered prior to in-depth treatment of cardiovascular disorders such as Doherty-Greenberg JM with Substitution... Md, PhD, Department of Pharmacology, dental School, University of Maryland at Baltimore of modalities.
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